Effect of the linking position of a side chain in bis(quinolylmethyl)ethylenediamine as a DNA binding agent.

نویسندگان

  • Y Mikata
  • Y Onchi
  • M Kishigami
  • S Yano
چکیده

Two bisquinoline derivatives, N,N'-bis(2-quinolylmethyl)ethylenediamine (2-BQME) and N,N'-bis(8-quinolylmethyl)ethylenediamine (8-BQME) have been synthesized, and their ability to bind to duplex DNA was studied. 8-BQME bound to DNA more strongly than 2-BQME, judging from the extent of increase in the melting temperature of duplex DNA, the UV-vis spectral change, and ethidium displacement assay. These compounds exhibited apparent AT-specificity suggesting minor groove binding in addition to intercalation.

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عنوان ژورنال:
  • Chemical & pharmaceutical bulletin

دوره 48 4  شماره 

صفحات  -

تاریخ انتشار 2000